AB0353 ADRENAL INSUFFICIENCY AFTER GLUCOCORTICOID TREATMENT OF GIANT CELL ARTERITIS
نویسندگان
چکیده
Background: Adrenal insufficiency is frequently neglected and underappreciated, potentially severe complication of systemic glucocorticoid therapy. Objectives: We aimed to evaluate the prevalence induced adrenal in giant cell arteritis (GCA). Methods: analysed function data a cohort GCA patients diagnosed between July 2014 2019, whom discontinuation methylprednisolone therapy was planned. tested by Corticotropin stimulation test (CST). To perform CST, substituted with hydrocortisone (20mg qd three divided doses) for one four weeks before test. defined as cortisol level <450 nmol/l measured 30 minutes after corticotropin injection; additionally, result CST borderline when injection 450 500 nmol/l. Results: 74/215 definite withdrawal (after median 13.5 (12.9 – 22.4) months therapy). The mean (SD) dose, prior substitution subsequent 3.1 (1.6) mg. detected 36/74 (48.6%); 10/74 (13.5%) had result. Seventeen either or result, repeated (IQR) 11.6 (8.9; 12.6) months. persisted 11/17 (64.7%) patients, 1/17 CST. A third performed 4/12 abnormal second 8.3 (6.9; 10.6) recovered patient, while remaining 3 patients. Conclusion: common long-lasting adverse event Disclosure Interests: None declared
منابع مشابه
Recovery of Adrenal Function after Long-Term Glucocorticoid Therapy for Giant Cell Arteritis: A Cohort Study
OBJECTIVES Giant cell arteritis (GCA) is a chronic systemic vasculitis of large and medium-sized arteries, for which long-term glucocorticoid (GC) treatment is needed. During GC withdrawal patients can suffer adrenal insufficiency. We sought to determine the time until recovery of adrenal function after long-term GC therapy, and to assess the prevalence and predictors for secondary adrenal insu...
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Author Affiliations:Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada (Bourassa, Dion, Rouleau); Group for AdvancedMolecular Investigation, Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil (Raskin); Genetika–Centro de Aconselhamento e Laboratório de G...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2021
ISSN: ['1468-2060', '0003-4967']
DOI: https://doi.org/10.1136/annrheumdis-2021-eular.323